# Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD

*PRI Rank #9 · Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 77 |
| Journal | Science Translational Medicine |
| Year | 2024 |
| DOI | 10.1126/scitranslmed.adg7162 |
| Corresponding authors | Sahba Seddighi, Yue Qi, Anna‐Leigh Brown, Leonard Petrucelli, Pietro Fratta, Michael E. Ward |
| Institution | National Institute of Neurological Disorders and Stroke, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026)

**Paper link:** [10.1126/scitranslmed.adg7162](https://doi.org/10.1126/scitranslmed.adg7162)

## Topics

TDP-43 · cryptic exons · amyotrophic lateral sclerosis · frontotemporal dementia · aberrant splicing · de novo proteins · human iPSC-derived neurons · cerebrospinal fluid · TDP-43 depletion · TDP-43 pathology · cryptic peptides · transcript variants · coordinated transcriptomic and proteomic studies · postmortem brain tissue · protein-protein interactions · ALS/FTD pathophysiology · cryptic exon translation · CSF biomarkers

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```