# Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier

*PRI Rank #5 · Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 94 |
| Journal | Science Translational Medicine |
| Year | 2024 |
| DOI | 10.1126/scitranslmed.adi2245 |
| Corresponding authors | Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim, David Tatarakis |
| Institution | Denali Therapeutics Inc., United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026)

**Paper link:** [10.1126/scitranslmed.adi2245](https://doi.org/10.1126/scitranslmed.adi2245)

## Topics

antisense oligonucleotides · blood-brain barrier · transferrin receptor 1 · oligonucleotide transport vehicle · TfR mu/hu KI mice · MALAT1 · systemic delivery · intrathecal delivery · CNS biodistribution · endothelial cells · neurons · astrocytes · microglia · oligodendrocytes · cynomolgus macaques · bivalent TfR antibody · RNA interference · intravenous injection · quadriceps muscle · cardiac muscle

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```