# Global impact of unproductive splicing on human gene expression

*PRI Rank #12 · Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 70 |
| Journal | Nature Genetics |
| Year | 2024 |
| DOI | 10.1038/s41588-024-01872-x |
| Corresponding authors | Yang Li |
| Institution | University of Chicago, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026)

**Paper link:** [10.1038/s41588-024-01872-x](https://doi.org/10.1038/s41588-024-01872-x)

## Topics

alternative splicing · nonsense-mediated decay · unproductive splicing · unproductive transcripts · AS-NMD · proteomic diversity · Gene regulation · population-scale genomic data · multi-intronic genes · genetic variation across cell lines · GWAS trait-associated loci · protein isoform usage · transcript degradation · cytoplasmic decay · steady-state RNA · NMD-induced expression changes

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```