# Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome

*PRI Rank #11 · Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 74 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adn8105 |
| Corresponding authors | Malgorzata Ewa Rogalska, Estefanía Mancini, Sophie Bonnal, Juan Valcárcel |
| Institution | Centre for Genomic Regulation (CRG), Spain |

**Ranking page:** [Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026)

**Paper link:** [10.1126/science.adn8105](https://doi.org/10.1126/science.adn8105)

## Topics

spliceosome · RNA splicing · alternative splicing · U4/U6.U5 tri-snRNP · U1 snRNP · splice site pairing · exon definition · alternative 5' splice site selection · transcriptome-wide analysis · systematic knock down · splicing factor networks · splicing factor cross-regulation · intron removal · spliceosome components · splicing regulators · core spliceosome

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```