# The diversity of splicing modifiers acting on A -1 bulged 5 -splice sites reveals rules for rational drug design

*PRI Rank #1 · Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 148 |
| Journal | HAL (Le Centre pour la Communication Scientifique Directe) |
| Year | 2024 |
| DOI | 10.1093/nar |
| Corresponding authors | Florian Malard |
| Institution | IECB, France |

**Ranking page:** [Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026)

**Paper link:** [10.1093/nar](https://doi.org/10.1093/nar)

## Topics

splicing modifiers · A-1 bulged 5'-splice sites · rational drug design · splice site recognition · U1 snRNA base pairing · bulged adenosine · spliceosome assembly · splicing correction · small molecule modulators · splice site strength · exon inclusion · RNA splicing · structure-activity relationships · U1 snRNP · cryptic splice sites

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Research and Splicing Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-research-and-splicing/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```