# Metabolic Recoding of NSUN2‐Mediated m<sup>5</sup>C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m<sup>5</sup>C‐ENO1 Positive Feedback Loop

*PRI Rank #5 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 76 |
| Journal | Advanced Science |
| Year | 2024 |
| DOI | 10.1002/advs.202309840 |
| Corresponding authors | Xiaoyu Xie, Xianghai Ren, Jianhong Zhao, Congqing Jiang |
| Institution | Zhongnan Hospital of Wuhan University, China |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1002/advs.202309840](https://doi.org/10.1002/advs.202309840)

## Topics

5-methylcytosine (m5C) · NSUN2 · YBX1 · ENO1 · colorectal cancer · m5C writer · m5C reader · metabolic reprogramming · lactate · H3K18la · NSUN2 K356 lactylation · NSUN2/YBX1/m5C-ENO1 positive feedback loop · post-transcriptional regulation · metabolic reprogramming · epigenetic remodeling · RNA modification · NSUN2 inhibitor · combination immunotherapy · oncogenic function · lactylation-mediated transcriptional activation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```