# Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer

*PRI Rank #3 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 105 |
| Journal | Drug Resistance Updates |
| Year | 2024 |
| DOI | 10.1016/j.drup.2024.101063 |
| Corresponding authors | Rongfang He, Yuehua Li, Hailin Tang |
| Institution | Sun Yat-sen University Cancer Center, China |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1016/j.drup.2024.101063](https://doi.org/10.1016/j.drup.2024.101063)

## Topics

GPRC5A · triple negative breast cancer · liver metastasis · docetaxel resistance · m6A · METTL3 · YTHDF1 · mTOR signaling pathway · mTORC1 · p70s6k · LAMTOR1 · single-cell RNA sequencing · MeRIP-seq · ubiquitination-dependent degradation · lysosomal recruitment · chemoresistance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```