# A hybrid residue based sequential encoding mechanism with XGBoost improved ensemble model for identifying 5-hydroxymethylcytosine modifications

*PRI Rank #18 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 49 |
| Journal | Scientific Reports |
| Year | 2024 |
| DOI | 10.1038/s41598-024-71568-z |
| Corresponding authors | Shahid Akbar, Thamer A. H. Alghamdi |
| Institution | Abdul Wali Khan University, Pakistan |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1038/s41598-024-71568-z](https://doi.org/10.1038/s41598-024-71568-z)

## Topics

5-hydroxymethylcytosine (5hmC) · 5-hydroxymethylcytosine (5hmC) · RNA modification · TET enzyme oxidation · 5-hydroxymethylcytosine (5hmC) · XGBoost · gradient boosting algorithm · residue based sequential encoding · hybrid vector · frequency residue based encoding features · SHAP · SHAP · feature selection · ensemble model · 10-fold cross-validation · epigenetic alterations · gene expression regulation · XGB5hmC

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```