# Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma

*PRI Rank #16 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 50 |
| Journal | Gut |
| Year | 2024 |
| DOI | 10.1136/gutjnl-2024-331903 |
| Corresponding authors | Irene Oi‐Lin Ng |
| Institution | The University of Hong Kong, Hong Kong |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1136/gutjnl-2024-331903](https://doi.org/10.1136/gutjnl-2024-331903)

## Topics

FTO · m6A · m6A erasers · hepatocellular carcinoma · extracellular vesicles · extracellular vesicles · GPNMB · syndecan-4 (SDC4) · YTHDF2 · CD8+ T cells · tumor-infiltrating lymphocytes · immune evasion · FTO inhibitor CS2 · anti-PD-1 therapy · sorafenib · m6A · mRNA stability · metastasis · immunotherapy sensitization

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```