# 5-methylcytosine methylation of MALAT1 promotes resistance to sorafenib in hepatocellular carcinoma through ELAVL1/SLC7A11-mediated ferroptosis

*PRI Rank #14 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 51 |
| Journal | Drug Resistance Updates |
| Year | 2024 |
| DOI | 10.1016/j.drup.2024.101181 |
| Corresponding authors | Jinfang Zhang |
| Institution | Guangzhou University of Chinese Medicine, China |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1016/j.drup.2024.101181](https://doi.org/10.1016/j.drup.2024.101181)

## Topics

5-methylcytosine (m5C) · MALAT1 · sorafenib resistance · hepatocellular carcinoma · ELAVL1 · SLC7A11 · ferroptosis · NSUN2 · ALYREF · mRNA stability · mRNA stability · cytoplasmic translocation · MALAT1-IN1 · 5-methylcytosine (m5C) · long non-coding RNAs · NSUN2/ALYREF/MALAT1 signaling axis · MALAT1/ELAVL1/SLC7A11 signaling axis · sorafenib-induced ferroptosis · epigenetic mechanisms

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```