# Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy

*PRI Rank #13 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 56 |
| Journal | EMBO Molecular Medicine |
| Year | 2024 |
| DOI | 10.1038/s44321-024-00025-1 |
| Corresponding authors | Xue Chen, Ying Wang, Jia-Nan Wang |
| Institution | Nanjing Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1038/s44321-024-00025-1](https://doi.org/10.1038/s44321-024-00025-1)

## Topics

diabetic retinopathy · FTO · m6A erasers · lactylation · CDK2 · microvascular anomalies · endothelial cells · angiogenesis · tip cell formation · EC-pericyte crosstalk · microvascular leakage · EC-microglia interactions · retinal inflammation · neurodegeneration · m6A-YTHDF2 axis · mRNA stability · histone lactylation · FB23-2 · nanoplatform · proliferative DR

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```