# ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice

*PRI Rank #11 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 60 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-46357-x |
| Corresponding authors | Li Zhang, Wei Lü, Guannan Zhang, Junli Zuo, Cheng‐Chao Ruan |
| Institution | Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1038/s41467-024-46357-x](https://doi.org/10.1038/s41467-024-46357-x)

## Topics

ALKBH5 · m6A · IL-11 · macrophage-to-myofibroblast transition · cardiac fibrosis · single-cell RNA sequencing · lineage tracing · parabiosis · angiotensin II-induced hypertension · m6A erasers · macrophage-specific knockout · MeRIP-seq · m6A demethylation · mRNA stability · IL11RA1 · targeted siRNA delivery · circulating monocytes · cardiac macrophages

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```