# NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis

*PRI Rank #10 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 61 |
| Journal | Redox Biology |
| Year | 2024 |
| DOI | 10.1016/j.redox.2024.103479 |
| Corresponding authors | Kaifeng Niu |
| Institution | China National Center for Bioinformation, China |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1016/j.redox.2024.103479](https://doi.org/10.1016/j.redox.2024.103479)

## Topics

NSUN2 · lactylation · ferroptosis resistance · GCLC · glutathione synthesis · m5C formation · mRNA stability · lipid peroxidation · doxorubicin · gastric cancer · NSUN2 K508R mutant · GCLC C-A mutant · NAA10 · lactytransferase · lactate treatment · tumor microenvironment · NAA10-NSUN2-GCLC axis · GSH levels

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```