# Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury

*PRI Rank #1 · Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 128 |
| Journal | Redox Biology |
| Year | 2024 |
| DOI | 10.1016/j.redox.2024.103194 |
| Corresponding authors | Hao Zhang, Changhong Miao |
| Institution | Zhongshan Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026)

**Paper link:** [10.1016/j.redox.2024.103194](https://doi.org/10.1016/j.redox.2024.103194)

## Topics

histone lactylation · H3K18la · METTL3 · ferroptosis · m6A · ACSL4 · sepsis-induced acute lung injury · lactate · p300 · YTHDC1 · alveolar epithelial cells · GPR81 · mRNA stability · mitochondria-associated ferroptosis · METTL3 inhibition · septic mice model

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA modifications and cancer Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-modifications-and-cancer/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```