# Charge-assisted stabilization of lipid nanoparticles enables inhaled mRNA delivery for mucosal vaccination

*PRI Rank #9 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 108 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-53914-x |
| Corresponding authors | Xueguang Lu |
| Institution | Chinese Academy of Sciences, China |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1038/s41467-024-53914-x](https://doi.org/10.1038/s41467-024-53914-x)

## Topics

Pulmonary delivery · Lipid nanoparticles · charge-assisted stabilization · Peptide-functionalized nanoparticles · Pulmonary delivery · electrostatic repulsion · colloidal stability · Pulmonary delivery · dendritic cell transfection · mucosal immune response · systemic immune response · SARS-CoV-2 Omicron vaccine · Cancer vaccines · lung metastasis inhibition · surface charge optimization · LNP aggregation · mucosal vaccination

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```