# Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain

*PRI Rank #8 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 113 |
| Journal | Nano Letters |
| Year | 2024 |
| DOI | 10.1021/acs.nanolett.4c05186 |
| Corresponding authors | Michael J. Mitchell |
| Institution | University of Pennsylvania, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1021/acs.nanolett.4c05186](https://doi.org/10.1021/acs.nanolett.4c05186)

## Topics

Peptide-functionalized nanoparticles · Systemic administration · Blood-brain barrier · RVG29 peptide · T7 peptide · AP2 peptide · mApoE peptide · click chemistry · brain endothelial cells · neuronal transfection · serum protein adsorption · intracellular trafficking · endothelial transcytosis · Extracellular vesicles (EVs) · hepatic accumulation · receptor targeting · Non-viral gene delivery vectors

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```