# In vivo editing of lung stem cells for durable gene correction in mice

*PRI Rank #7 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 113 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adk9428 |
| Corresponding authors | Yehui Sun, Sumanta Chatterjee, Daniel J. Siegwart |
| Institution | The University of Texas Southwestern Medical Center, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1126/science.adk9428](https://doi.org/10.1126/science.adk9428)

## Topics

Lipid nanoparticles · Gene editing · lung stem cells · adenine base editor · NG-ABE8e · Cystic Fibrosis · CFTR · R553X nonsense mutation · F508del · intravenous administration · Ai9 reporter mice · patient-derived bronchial epithelial cells · intestinal organoids · Trikafta · Gene editing · CFTR function restoration · sgR553X · lung epithelial cells · CF mouse model

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```