# Direct cytosolic delivery of siRNA via cell membrane fusion using cholesterol-enriched exosomes

*PRI Rank #3 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 126 |
| Journal | Nature Nanotechnology |
| Year | 2024 |
| DOI | 10.1038/s41565-024-01785-0 |
| Corresponding authors | Yong Gan, Guoqing Hu, Miaorong Yu |
| Institution | Chinese Academy of Sciences, China |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1038/s41565-024-01785-0](https://doi.org/10.1038/s41565-024-01785-0)

## Topics

siRNA delivery · cytosolic delivery · Membrane fusion · cholesterol-enriched exosomes · Extracellular vesicles (EVs) · RNA interference · Membrane fusion · cholesterol modification · endosomal escape · therapeutic RNA delivery

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```