# Polymer-locking fusogenic liposomes for glioblastoma-targeted siRNA delivery and CRISPR–Cas gene editing

*PRI Rank #20 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 82 |
| Journal | Nature Nanotechnology |
| Year | 2024 |
| DOI | 10.1038/s41565-024-01769-0 |
| Corresponding authors | Yu Zhao, Xintong Hou, Xiangqi Meng, Chuanlu Jiang, Jinquan Cai |
| Institution | The Second Affiliated Hospital of Harbin Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1038/s41565-024-01769-0](https://doi.org/10.1038/s41565-024-01769-0)

## Topics

Fusogenic liposomes · glioblastoma · siRNA delivery · CRISPR-Cas gene editing · Fusogenic liposomes · polymer-locking mechanism · Blood-brain barrier · Membrane fusion · nanoparticle delivery · gene silencing · genome editing · brain tumor targeting · Lipid nanoparticles · therapeutic delivery platform

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```