# A bioswitchable delivery system for microRNA therapeutics based on a tetrahedral DNA nanostructure

*PRI Rank #18 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 85 |
| Journal | Nature Protocols |
| Year | 2024 |
| DOI | 10.1038/s41596-024-01050-7 |
| Corresponding authors | Xiaoxiao Cai |
| Institution | Sichuan University, China |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1038/s41596-024-01050-7](https://doi.org/10.1038/s41596-024-01050-7)

## Topics

Stimuli-responsive nanocarrier · microRNA therapeutics · DNA nanotechnology · DNA nanotechnology · Targeted drug delivery · Stimuli-responsive nanocarrier · Nucleic acid delivery · RNA therapeutics · DNA nanotechnology · controlled release · biocompatible nanostructure · Non-viral gene delivery vectors

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```