# Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d

*PRI Rank #17 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 86 |
| Journal | Nature Biomedical Engineering |
| Year | 2024 |
| DOI | 10.1038/s41551-024-01256-w |
| Corresponding authors | Kathryn A. Whitehead |
| Institution | Carnegie Mellon University, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1038/s41551-024-01256-w](https://doi.org/10.1038/s41551-024-01256-w)

## Topics

Ionizable lipids · Lipid nanoparticles · amine headgroups · TLR4 · CD1d · immune responses · Receptor-ligand interactions · innate immunity · Lipid design · Immunogenicity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```