# RNA aggregates harness the danger response for potent cancer immunotherapy

*PRI Rank #15 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 93 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.04.003 |
| Corresponding authors | Hector R Mendez-Gomez |
| Institution | University of Florida, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1016/j.cell.2024.04.003](https://doi.org/10.1016/j.cell.2024.04.003)

## Topics

RNA aggregates · danger response · cancer immunotherapy · Immunogenicity · pattern recognition receptors · Immunogenicity · tumor microenvironment · antitumor immunity · therapeutic RNA delivery · Immunogenicity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```