# Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier

*PRI Rank #14 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 94 |
| Journal | Science Translational Medicine |
| Year | 2024 |
| DOI | 10.1126/scitranslmed.adi2245 |
| Corresponding authors | Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim, David Tatarakis |
| Institution | Denali Therapeutics Inc., United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1126/scitranslmed.adi2245](https://doi.org/10.1126/scitranslmed.adi2245)

## Topics

antisense oligonucleotides · Blood-brain barrier · Transferrin receptor 1 · oligonucleotide transport vehicle · Human TFRC knockin mice · Malat1 · Systemic administration · intrathecal delivery · CNS biodistribution · endothelial cells · neurons · astrocytes · microglia · oligodendrocytes · cynomolgus macaques · bivalent TfR antibody · RNA-targeted therapies · intravenous administration · quadriceps muscle · cardiac muscle

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```