# Strategies to reduce the risks of mRNA drug and vaccine toxicity

*PRI Rank #13 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 98 |
| Journal | Nature Reviews Drug Discovery |
| Year | 2024 |
| DOI | 10.1038/s41573-023-00859-3 |
| Corresponding authors | Mansoor M. Amiji |
| Institution | Northeastern University, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1038/s41573-023-00859-3](https://doi.org/10.1038/s41573-023-00859-3)

## Topics

mRNA therapeutics · mRNA vaccines · toxicity · risk reduction strategies · Immunogenicity · Immunogenicity · Nucleoside modifications · Lipid nanoparticles · dose optimization · Drug delivery systems · inflammatory responses · translation efficiency · RNA stability · Nucleoside modifications · codon optimization · Immunogenicity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```