# An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery

*PRI Rank #12 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 100 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adm8386 |
| Corresponding authors | Qin Huang, Ken Y. Chan, Benjamin E. Deverman |
| Institution | Broad Institute of MIT and Harvard, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1126/science.adm8386](https://doi.org/10.1126/science.adm8386)

## Topics

Adeno-associated virus (AAV) · BI-hTFR1 · Transferrin receptor 1 · Transferrin receptor 1 · Blood-brain barrier · CNS drug delivery · transcytosis · human brain endothelial cells · Adeno-associated virus (AAV) · Human TFRC knockin mice · CNS drug delivery · GBA1 gene · Gaucher disease · Parkinson's disease · glucocerebrosidase activity · cerebrospinal fluid · CNS drug delivery · receptor-mediated transport

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```