# Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

*PRI Rank #1 · Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 169 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-50093-7 |
| Corresponding authors | Ping Yuan, Zhen Gu, Shuai Liu |
| Institution | Zhejiang University, China |

**Ranking page:** [Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026)

**Paper link:** [10.1038/s41467-024-50093-7](https://doi.org/10.1038/s41467-024-50093-7)

## Topics

Lipid nanoparticles · organ-targeted mRNA delivery · Ionizable lipids · Biodegradable lipids · cholesterol-removal · Pulmonary delivery · Liver targeting · mRNA accumulation · mRNA translation · LNP composition optimization · combinatorial lipid library · Lipid nanoparticles · Lipid nanoparticles · Biodistribution · Pulmonary delivery · Liver targeting

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA Interference and Gene Delivery Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-interference-and-gene-delivery/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```