# DNA damage induces p53-independent apoptosis through ribosome stalling

*PRI Rank #7 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 72 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adh7950 |
| Corresponding authors | Rafaela A. Oliveira, Pierre-René Körner, Adva Kochavi, Reuven Agami, Thijn R. Brummelkamp |
| Institution | Oncode Institute, Netherlands |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1126/science.adh7950](https://doi.org/10.1126/science.adh7950)

## Topics

p53-independent apoptosis · DNA damage · ribosome stalling · UUA codons · translation inhibition · SLFN11 · GCN2 · ZAKα · ribotoxic stress · tRNA anticodon targeting · leucine-encoding codons · translation initiation · genetic screen · ribosome sensor · chemotherapy resistance · cell fate signaling

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```