# Metabolic Recoding of NSUN2‐Mediated m<sup>5</sup>C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m<sup>5</sup>C‐ENO1 Positive Feedback Loop

*PRI Rank #6 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 76 |
| Journal | Advanced Science |
| Year | 2024 |
| DOI | 10.1002/advs.202309840 |
| Corresponding authors | Xiaoyu Xie, Xianghai Ren, Jianhong Zhao, Congqing Jiang |
| Institution | Zhongnan Hospital of Wuhan University, China |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1002/advs.202309840](https://doi.org/10.1002/advs.202309840)

## Topics

5-methylcytosine (m5C) · NSUN2 · YBX1 · ENO1 · colorectal cancer (CRC) · m5C methyltransferase · m5C reader protein · glucose metabolism reprogramming · lactic acid production · histone H3K18 lactylation (H3K18la) · NSUN2 K356 lactylation · NSUN2/YBX1/m5C-ENO1 positive feedback loop · post-transcriptional regulation · metabolic reprogramming · epigenetic remodeling · RNA modifications · NSUN2 inhibitor · immunotherapy combination · oncogenic function · lactylation-mediated transcriptional activation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```