# 2′-O-methylation at internal sites on mRNA promotes mRNA stability

*PRI Rank #20 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 44 |
| Journal | Molecular Cell |
| Year | 2024 |
| DOI | 10.1016/j.molcel.2024.04.011 |
| Corresponding authors | Qi Cao, Kaifu Chen |
| Institution | Boston Children's Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1016/j.molcel.2024.04.011](https://doi.org/10.1016/j.molcel.2024.04.011)

## Topics

2'-O-methylation · internal mRNA modification · mRNA stability · RNA methylation · post-transcriptional regulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```