# The diversity of splicing modifiers acting on A -1 bulged 5 -splice sites reveals rules for rational drug design

*PRI Rank #2 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 148 |
| Journal | HAL (Le Centre pour la Communication Scientifique Directe) |
| Year | 2024 |
| DOI | 10.1093/nar |
| Corresponding authors | Florian Malard |
| Institution | ARNA - Acides Nucléiques : Régulations Naturelle et Artificielle (IECB - 2 rue Robert Escarpit 33607 Pessac. - France), France |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1093/nar](https://doi.org/10.1093/nar)

## Topics

splicing modifiers · A-1 bulged 5'-splice sites · structure-based drug design · splice site recognition · U1 snRNA base pairing · bulged adenosine · spliceosome assembly · splicing correction · small molecule modulators · splice site strength · exon inclusion · mRNA splicing · structure-activity relationships · U1 snRNP · cryptic splice sites

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```