# The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A

*PRI Rank #18 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 45 |
| Journal | Nature Structural & Molecular Biology |
| Year | 2024 |
| DOI | 10.1038/s41594-023-01196-0 |
| Corresponding authors | Christopher S. Fraser, V. Ramakrishnan |
| Institution | MRC Laboratory of Molecular Biology, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1038/s41594-023-01196-0](https://doi.org/10.1038/s41594-023-01196-0)

## Topics

translation initiation complex · translation initiation complex · translation initiation complex · eIF4F · eIF4A helicase · cap-binding complex · mRNA exit channel · mRNA entry site · 40S ribosomal subunit · mRNA secondary structure unwinding · start codon recognition · mRNA scanning · mRNA recruitment · cryo-electron microscopy · eIF4F-43S interactions

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```