# DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability

*PRI Rank #14 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 47 |
| Journal | Molecular Cell |
| Year | 2024 |
| DOI | 10.1016/j.molcel.2024.03.006 |
| Corresponding authors | Qian-Lan Liu, Yun‐Gui Yang, Jie Ren |
| Institution | Chinese Academy of Sciences, China |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1016/j.molcel.2024.03.006](https://doi.org/10.1016/j.molcel.2024.03.006)

## Topics

DDX21 · co-transcriptional RNA m6A modification · transcription termination · genome stability · RNA helicase · N6-methyladenosine (m6A) · METTL3 · METTL14 · m6A writer complex · R-loops · transcription-replication conflicts · RNA processing · chromatin association · DNA damage · nascent RNA · epitranscriptome

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```