# Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism

*PRI Rank #13 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 48 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-023-06897-6 |
| Corresponding authors | Jason W. Chin |
| Institution | Medical Research Council Laboratory of Molecular Biology, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1038/s41586-023-06897-6](https://doi.org/10.1038/s41586-023-06897-6)

## Topics

tRNA display · orthogonal aminoacyl-tRNA synthetases · non-canonical monomers · β-amino acids · α,α-disubstituted amino acids · β-hydroxy acids · orthogonal tRNAs · genetic code engineering · ribosomal substrates · evolutionary deadlock · site-specific incorporation · Escherichia coli · non-canonical amino acids · synthetase selection · tRNA acylation · macrocyclic peptides · depsipeptides · encoded polymer synthesis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```