# IGF2BP3 promotes mRNA degradation through internal m7G modification

*PRI Rank #12 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 50 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-51634-w |
| Corresponding authors | Chuan He |
| Institution | The University of Chicago, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1038/s41467-024-51634-w](https://doi.org/10.1038/s41467-024-51634-w)

## Topics

IGF2BP3 · mRNA degradation · m7G modification · METTL1–WDR4 complex · IGF2BP family proteins · IGF2BP1 · IGF2BP2 · N6-methyladenosine (m6A) · TP53 transcript · 3'UTR m7G methylation · glioblastoma · dCas13b-guided system · site-specific m7G targeting · mRNA half-life regulation · mRNA stability · chemosensitivity · cancer progression · RNA methylation reader proteins

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```