# Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation

*PRI Rank #11 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 58 |
| Journal | Nature Biotechnology |
| Year | 2024 |
| DOI | 10.1038/s41587-024-02393-y |
| Corresponding authors | Xiao Wang |
| Institution | Massachusetts Institute of Technology, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1038/s41587-024-02393-y](https://doi.org/10.1038/s41587-024-02393-y)

## Topics

multicapped mRNA · capped circular RNA · translation augmentation · chemical design · topological design · mRNA capping · circular RNA · translation efficiency · cap structure · RNA topology

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```