# Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

*PRI Rank #10 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 61 |
| Journal | Nature Biotechnology |
| Year | 2024 |
| DOI | 10.1038/s41587-024-02174-7 |
| Corresponding authors | Xiao Wang |
| Institution | Massachusetts Institute of Technology, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1038/s41587-024-02174-7](https://doi.org/10.1038/s41587-024-02174-7)

## Topics

branched poly(A) tails · chemically modified poly(A) tails · multitailed mRNA · mRNA translation capacity · mRNA stability · protein expression duration · synthetic poly(A) tails · topologically modified mRNA · capped branched mRNA · multiplexed genome editing · Pcsk9 · Angptl3 · mouse liver · mRNA therapeutics · mRNA transfection · in vivo protein expression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```