# Sequence modeling and design from molecular to genome scale with Evo

*PRI Rank #1 · Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 369 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.ado9336 |
| Corresponding authors | Eric Nguyen, Michael Poli, Matthew G. Durrant, Brian Kang, Dhruva Katrekar, David Li, Patrick D. Hsu, Brian Hie |
| Institution | Arc Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026)

**Paper link:** [10.1126/science.ado9336](https://doi.org/10.1126/science.ado9336)

## Topics

Evo · long-context genomic foundation model · prokaryotic genomes · phage genomes · scaling laws on DNA · zero-shot prediction · CRISPR-Cas system generation · transposon system generation · protein-RNA codesign · protein-DNA codesign · variant effect prediction · whole-organism fitness · megabase-scale sequence generation · 3D genome organization · cross-modality generalization · DNA language model · RNA language model · protein language model

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited RNA and protein synthesis mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/rna-and-protein-synthesis-mechanisms/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```