# Gene Editing for <i>CEP290</i> -Associated Retinal Degeneration

*PRI Rank #3 · Topics and Trends in Most Cited Retinal Diseases and Treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-diseases-and-treatments/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 118 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2309915 |
| Corresponding authors | Eric A Pierce |
| Institution | From the Ocular Genomics Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited Retinal Diseases and Treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-diseases-and-treatments/2026)

**Paper link:** [10.1056/nejmoa2309915](https://doi.org/10.1056/nejmoa2309915)

## Topics

EDIT-101 · CEP290 IVS26 variant · CRISPR-Cas9 gene editing · in vivo gene editing · Subretinal injection · Leber congenital amaurosis · Inherited retinal degeneration · full-field stimulus testing · Best-corrected visual acuity (BCVA) · Ora-Visual Navigation Challenge mobility test · National Eye Institute Visual Function Questionnaire-25 · Children's Visual Function Questionnaire · Photoreceptors · dose-limiting toxicity assessment · photoreceptor gene therapy · BRILLIANCE clinical trial

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Diseases and Treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-diseases-and-treatments/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```