# Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results

*PRI Rank #13 · Topics and Trends in Most Cited Retinal Diseases and Treatments Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-diseases-and-treatments/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 57 |
| Journal | Nature Medicine |
| Year | 2024 |
| DOI | 10.1038/s41591-024-02802-4 |
| Corresponding authors | Przemysław Sapieha |
| Institution | University of Montreal, Canada |

**Ranking page:** [Topics and Trends in Most Cited Retinal Diseases and Treatments Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-diseases-and-treatments/2026)

**Paper link:** [10.1038/s41591-024-02802-4](https://doi.org/10.1038/s41591-024-02802-4)

## Topics

cellular senescence · Diabetic macular edema · Senolytic therapy · phase 1 clinical trial · Retinal pigment epithelium · senescence-associated secretory phenotype · vascular endothelial growth factor · Optical coherence tomography · Central subfield thickness · p16INK4a · p21 · SA-β-galactosidase · dasatinib · quercetin · Anti-VEGF therapy · Diabetic retinopathy · Central subfield thickness · Senolytic therapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Diseases and Treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-diseases-and-treatments/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```