# Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma

*PRI Rank #9 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 33 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-023-44380-y |
| Corresponding authors | Ayellet V. Segrè |
| Institution | Harvard University, United States |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1038/s41467-023-44380-y](https://doi.org/10.1038/s41467-023-44380-y)

## Topics

primary open-angle glaucoma · intraocular pressure · RGC death · colocalization analysis · Mendelian randomization · GWAS loci · expression quantitative trait loci · splicing quantitative trait loci · GTEx tissues · extracellular matrix organization · Single-nucleus RNA sequencing · aqueous outflow pathways · optic nerve head · peripapillary sclera · choroid · IOP-dependent mechanisms · IOP-independent mechanisms · vascular development · cell adhesion pathways

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```