# 6PPD, Not 6PPD-Quinone, Induced Serious Zebrafish Eye Damage by Disrupting the Thyroid Signaling Pathway

*PRI Rank #6 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 37 |
| Journal | Environmental Science & Technology |
| Year | 2024 |
| DOI | 10.1021/acs.est.4c11264 |
| Corresponding authors | Bin Wan |
| Institution | Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, China |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1021/acs.est.4c11264](https://doi.org/10.1021/acs.est.4c11264)

## Topics

6PPD · 6PPD-quinone · 6PPD · 6PPD-quinone · zebrafish eye damage · thyroid signaling pathway · thyroid hormone receptor · TR antagonist · microphthalmus · opsin protein · cone photoreceptor cell proliferation · retinal layer structure · phototactic behavior · GH3 cell · trβ · opn1lw1 · opn1mw1 · rpe65a · nr2e3 · molecular docking

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```