# Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina

*PRI Rank #5 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 37 |
| Journal | Science Advances |
| Year | 2024 |
| DOI | 10.1126/sciadv.adn2091 |
| Corresponding authors | Seth Blackshaw, Thanh Hoang |
| Institution | Johns Hopkins University, United States |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1126/sciadv.adn2091](https://doi.org/10.1126/sciadv.adn2091)

## Topics

direct reprogramming · retinal glial cells · Müller glia · Notch signaling · Rbpj · Notch1/2 · bipolar cells · amacrine cells · neurogenic basic helix-loop-helix (bHLH) factors · nuclear factor I (NFI) factors · Nfia/b/x · Yap overexpression · neurogenic competence · Inherited retinal degeneration · Glial-to-neuronal conversion · Müller glial proliferation · Notch effector genes

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```