# A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells

*PRI Rank #4 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 39 |
| Journal | Proceedings of the National Academy of Sciences |
| Year | 2024 |
| DOI | 10.1073/pnas.2317285121 |
| Corresponding authors | Jason S. Meyer |
| Institution | Indiana University, United States |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1073/pnas.2317285121](https://doi.org/10.1073/pnas.2317285121)

## Topics

Retinal organoid · Pluripotent stem cells · Retinal organoid · quick reaggregation methods · BMP signaling · forebrain fate specification · Cell fate specification · RNA sequencing · Retinal development · organoid size and shape regulation · default forebrain fate · transcriptional changes · lineage specification · differentiation timeline · three-dimensional cellular aggregates · self-organization · temporal patterning · spatial patterning

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```