# Phase 1/2 AAV5-hRKp.RPGR (Botaretigene Sparoparvovec) Gene Therapy: Safety and Efficacy in RPGR-Associated X-Linked Retinitis Pigmentosa

*PRI Rank #18 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 24 |
| Journal | American Journal of Ophthalmology |
| Year | 2024 |
| DOI | 10.1016/j.ajo.2024.05.034 |
| Corresponding authors | Michel Michaelides |
| Institution | UCL Institute of Ophthalmology, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1016/j.ajo.2024.05.034](https://doi.org/10.1016/j.ajo.2024.05.034)

## Topics

AAV5-hRKp.RPGR · botaretigene sparoparvovec · RPGR · X-linked retinitis pigmentosa · XLRP · gene therapy · dose escalation · Subretinal injection · static perimetry · Microperimetry · vision-guided behavior · Retinal sensitivity · Retinal detachment · uveitis · corticosteroid treatment · functional vision outcomes · pediatric patients · randomized immediate versus deferred treatment · Phase 1/2 clinical trial

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```