# An adeno-associated virus variant enabling efficient ocular-directed gene delivery across species

*PRI Rank #15 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 26 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-48221-4 |
| Corresponding authors | Xiao Ke, Qiang Zheng, Xun Sun |
| Institution | Chengdu Origen Biotechnology Co. Ltd, China |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1038/s41467-024-48221-4](https://doi.org/10.1038/s41467-024-48221-4)

## Topics

AAVv128 · adeno-associated virus capsid · suprachoroidal injection · photoreceptor transduction · Retinal pigment epithelium · intraocular injection · Anti-VEGF therapy · laser-induced choroidal neovascularization · neovascular AMD · nonhuman primate · cryo-EM structure · AAV binding residues · nuclear uptake · endosome escape · retinal tissue distribution · ocular gene delivery · Grade IV lesion suppression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```