# Disease Activity and Therapeutic Response to Pegcetacoplan for Geographic Atrophy Identified by Deep Learning-Based Analysis of OCT

*PRI Rank #14 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 26 |
| Journal | Ophthalmology |
| Year | 2024 |
| DOI | 10.1016/j.ophtha.2024.08.017 |
| Corresponding authors | Ursula Schmidt‐Erfurth |
| Institution | Medical University of Vienna, Austria |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1016/j.ophtha.2024.08.017](https://doi.org/10.1016/j.ophtha.2024.08.017)

## Topics

pegcetacoplan · geographic atrophy · deep learning segmentation · Optical coherence tomography · photoreceptor degeneration · retinal pigment epithelium loss · ellipsoid zone loss · EZ-RPE difference · age-related macular degeneration · OAKS trial · DERBY trial · therapeutic response stratification · disease activity biomarker · complement inhibition · longitudinal morphological analysis · phase 3 trial · RPE loss growth rate · EZ loss growth rate · baseline EZ-RPE quartiles

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```