# Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina

*PRI Rank #13 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 26 |
| Journal | Proceedings of the National Academy of Sciences |
| Year | 2024 |
| DOI | 10.1073/pnas.2311028121 |
| Corresponding authors | Yidan Liu, Xiuxing Liu, Xuhao Chen, Zhenlan Yang, Yehong Zhuo, Wenru Su |
| Institution | Sun Yat-sen University, China |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1073/pnas.2311028121](https://doi.org/10.1073/pnas.2311028121)

## Topics

procyanidin C1 · senolytic agents · senomorphic agents · cellular senescence · senescence-associated secretory phenotype · aged retina · retinal structural decline · retinal functional decline · Single-cell RNA sequencing · scRNA-seq · mouse models of natural aging · retinal landscape · Senescent cell accumulation · age-related retinal disorders · Senescent cell accumulation · retinal impairment

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```