# Gene Editing for <i>CEP290</i> -Associated Retinal Degeneration

*PRI Rank #1 · Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 118 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2309915 |
| Corresponding authors | Eric A Pierce |
| Institution | Mass Eye and Ear, United States |

**Ranking page:** [Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026](https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026)

**Paper link:** [10.1056/nejmoa2309915](https://doi.org/10.1056/nejmoa2309915)

## Topics

CEP290 · Inherited retinal degeneration · IVS26 variant · EDIT-101 · CRISPR-Cas9 gene editing · Subretinal injection · Best-corrected visual acuity · Full-field stimulus testing · Ora–Visual Navigation Challenge · National Eye Institute Visual Function Questionnaire–25 · Children's Visual Function Questionnaire · cone-mediated vision · photoreceptor function · in vivo genome editing · Phase 1/2 clinical trial

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Retinal Development and Disorders Papers, Class of 2026. https://pri.pepkio.com/top-papers/retinal-development-and-disorders/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```