# An integrated microbiome- and metabolome-genome-wide association study reveals the role of heritable ruminal microbial carbohydrate metabolism in lactation performance in Holstein dairy cows

*PRI Rank #2 · Topics and Trends in Most Cited Reproductive Physiology in Livestock Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-physiology-in-livestock/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 27 |
| Journal | Microbiome |
| Year | 2024 |
| DOI | 10.1186/s40168-024-01937-3 |
| Corresponding authors | Shengru Wu, Sharon Huws, Junhu Yao |
| Institution | Northwest A&F University, China |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Physiology in Livestock Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-physiology-in-livestock/2026)

**Paper link:** [10.1186/s40168-024-01937-3](https://doi.org/10.1186/s40168-024-01937-3)

## Topics

Rumen microbiome · host genetics · heritability · metagenome · metabolome · whole-genome resequencing · short-chain fatty acids (SCFAs) · Energy-corrected milk · Acetate:propionate ratio · genome-wide association study · Microbiome-wide association study · metabolome-GWAS · Microbiome-wide association study · SLC30A9 · Prevotella sp. · carbohydrate-active enzymes (CAZy) · glycoside hydrolase families (GH10, GH13, GH43, GH95, GH115, GH24) · Pseudobutyrivibrio sp. · 9,10,13-TriHOME · structural equation model (SEM)

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Physiology in Livestock Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-physiology-in-livestock/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```