# Alterations in the gut microbiota and its metabolites contribute to metabolic maladaptation in dairy cows during the development of hyperketonemia

*PRI Rank #14 · Topics and Trends in Most Cited Reproductive Physiology in Livestock Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/reproductive-physiology-in-livestock/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 17 |
| Journal | mSystems |
| Year | 2024 |
| DOI | 10.1128/msystems.00023-24 |
| Corresponding authors | Zhengzhong Luo, Zhenlong Du, Yixin Huang |
| Institution | Sichuan Agricultural University, China |

**Ranking page:** [Topics and Trends in Most Cited Reproductive Physiology in Livestock Papers, Class of 2026](https://pri.pepkio.com/top-papers/reproductive-physiology-in-livestock/2026)

**Paper link:** [10.1128/msystems.00023-24](https://doi.org/10.1128/msystems.00023-24)

## Topics

hyperketonemia · β-hydroxybutyrate · Gut microbiome · Transition dairy cows · multi-omics analysis · Fecal microbiota · Verrucomicrobiota · Proteobacteria · Frisingicoccus · Random forest · branched-chain amino acids · ketogenesis pathway · taurodeoxycholic acid · secondary bile acids · excessive lipolysis · insulin resistance · Lipid mobilization · metabolic maladaptation · calving-associated metabolism · microbial metabolites

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Reproductive Physiology in Livestock Papers, Class of 2026. https://pri.pepkio.com/top-papers/reproductive-physiology-in-livestock/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```